To further investigate the role of AMPK and HSF1 in PDAC, we generated LSL‐KrasG12D/+; p53 fl/+; Pdx1‐Cre (KPC) transgenic mice that recapitulate the spectrum of pancreatic cancer from pancreatic intraepithelial neoplasia (PanIN) to invasive PDAC (Lee et al., 2016). This evidence concerns the gene TP53 and pancreatic neoplasm.