To further investigate the role of AMPK and HSF1 in PDAC, we generated LSL‐KrasG12D/+; p53 fl/+; Pdx1‐Cre (KPC) transgenic mice that recapitulate the spectrum of pancreatic cancer from pancreatic intraepithelial neoplasia (PanIN) to invasive PDAC (Lee et al., 2016). The gene discussed is PDX1; the disease is familial pancreatic carcinoma.