In breast cancer, nearly 80% of in situ and invasive breast carcinomas expressed high levels of HSF1, which was associated with a high histological grade, a larger tumor size, and nodal involvement; those with HSF1‐positive tumors had significantly reduced survival rates compared with women with HSF1‐negative tumors (Santagata et al., 2011). This evidence concerns the gene HSF1 and neoplasm.