ZEB2 and neoplasm: ZEB2 protein may have an oncosuppressive role by inhibiting cell cycle progression and maintaining cell differentiation.6, 7, 9, 36 In contrast, ZEB1 drives EMT pathways, which cooperate with classical oncogenes in malignant transformation.9, 37 Therefore, the physiological outcomes of EMT programs activated by ZEB proteins in tumor cells are often different.