ZEB2 represses cyclin D1 or hTERT leading to the reversible cell cycle arrest or cellular senescence.6, 7 In cells of cutaneous melanoma, ZEB2 increases expression levels of a tumor suppressor protein PTEN8, and promotes melanocytic differentiation through upregulation of MITF.9 In contrast, ZEB1 does not possess these oncosuppressive functions. The gene discussed is ZEB2; the disease is cutaneous melanoma.