Estradiol is locally produced in the NSCLC mainly by aromatase, which is localized in both the epithelial cell components of lung tumors as well as in the infiltrating macrophages; even exclusively confined to the inflammatory cells infiltrated in the pre-neoplastic and neoplastic areas in some of the animal models [88,89]. Here, CYP19A1 is linked to non-small cell lung carcinoma.