Continuous luminal sampling of intestinal microbiota and periodic epithelial breaches during gastrointestinal infections might provide a plethora of memory T cells with potential reactivity toward newly encountered pathogens.6, 7 Therefore, contrary to the notion that they promote inflammatory pathology, acquired commensal-reactive T-cell responses may be essential to promote barrier function and IL10-mediated immune regulation—2 cornerstones of intestinal homeostasis. Here, IL10 is linked to digestive system infectious disorder.