NOTCH1 and neoplasm: This patient's tumor demonstrated 8 mutations overall including alterations in the PI3K, MAPK pathways (mutations in FBXW7, FGFR1) with concurrent epigenetic and transcriptional deregulation, specifically ARID1A, ETV1 rearrangement, NOTCH1 APIP-NOTCH1 fusion, and MYST3 amplification.