TP53 and adenocarcinoma: Most commonly, five patients had 6 unique aberrations within TP53, specifically R273C, R248Q, R 196*, and R248W including one patient with an adenocarcinoma who had a dual mutation within TP53 with a relatively uncommon N-terminal missense mutation L45P and a concurrent Q38fs*79, which is frameshift mutation leading to the truncation of the p53 protein prior to the conserved DNA-binding domain region.