POU5F1 and hepatocellular carcinoma: As shown in Fig. 3, overexpression of MENA dramatically upregulated the mRNA levels of hepatic progenitor cell (HPC) markers CK19 and EpCAM, stem cell markers Oct4 and Sox2, and Wnt signaling marker β‐catenin in both stable MENA HCC cell lines as compared with their vector control counterparts (Fig. 3A,B).