In addition, we did not simultaneously implement the results for another MENA‐overexpressing cell (SMMC‐7721‐MENA cell) in this study, and the immunofluorescence data of colocalization of MENA and stem cell markers (CK19 and CD133) in human HCC tissues are important to validate MENA as a stemness marker. Here, PROM1 is linked to hepatocellular carcinoma.