As shown in Fig. 3, overexpression of MENA dramatically upregulated the mRNA levels of hepatic progenitor cell (HPC) markers CK19 and EpCAM, stem cell markers Oct4 and Sox2, and Wnt signaling marker β‐catenin in both stable MENA HCC cell lines as compared with their vector control counterparts (Fig. 3A,B). The gene discussed is SOX2; the disease is hepatocellular carcinoma.