The two terms of GO:0003682 of ‘chromatin binding’ and GO:0000979 of ‘RNA polymerase II core promoter sequence‐specific DNA binding’ have three repeated genes of GATA3, TP53, and YAP1 with fold changes of −2.71, −2.02, and −2.08, respectively, following knockdown of SMYD3 in ESCC. Here, SMYD3 is linked to esophageal squamous cell carcinoma.