Myriads of reports (Patrick, 2009; Jugan et al., 2010) suggest that thyroid disruptors can target the thyroid endocrine cascade at various levels encompassing several molecular components of the hypothalamus–pituitary–thyroid-periphery (HPTP) axis as well as the functioning of the peripheral tissues including; iodine uptake, thyroid hormone production, interconversion of thyroid hormones, cellular uptake and cell receptor activation. The gene discussed is TG; the disease is thyroid gland disorder.