CLPTM1L and cancer: In human cutaneous melanoma, recurrent mutations in the TERT promoter have previously been identified.18 A single UM tumor has been reported as carrying a mutation in the TERT promoter (chr5:1,295,226G > A) leading to elevated TERT expression.19 However, TERT was not significantly expressed in any of the UM tumors included in our study leading us to focus on the adjacent gene CLPTM1L. Some variants of CLPTM1L have previously been negatively or positively associated with different cancers.