The embryonic-induced mice developed tumours similar to those seen in the Hesx1 model36, with identifiable β-catenin-accumulating cluster cells reminiscent of those in human aCP that were quiescent or slow-dividing (did not express Ki-67) and were undifferentiated (did not express lineage commitment markers αGSU and PIT1)37. Here, HESX1 is linked to neoplasm.