KLRC2 and cytomegalovirus infection: During persistent HCMV infection of healthy virus carriers, after HCMV reactivation in bone marrow transplant patients, in HCMV-infected children, and in HCMV-infected individuals with asymptomatic co-infections23,36–38, terminally differentiated NK cells (phenotypically CD56dimCD16+KIR+LIR1+NKG2C+CD57+Bcl-2+NKG2A-NKp46lowNKp30lowCD161lowCD7lowTim-3lowPZLFlowSyklowEat-2lowDAB2lowHelioslowFcεR1γlowCD2high) with many epigenetically silenced gene loci accumulate (Figure 1)39–42.