IL6 and Parkinson disease: Moreover, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced Parkinson's disease (PD) mouse model, Lofrumento et al. revealed that resveratrol treatment significantly reduced glial activation and decreased the levels of IL-1β, IL-6, and TNF-α in the brain tissue by upregulating the SOCS1 protein expression [38].