INS and obesity due to melanocortin 4 receptor deficiency: Although Ballak et al. found that elevated IL-37 levels positively correlate with insulin sensitivity and a lower inflammatory status in human adipose tissue and that IL-37 ameliorates obesity-induced inflammation and insulin resistance in transgenic mice, the reasonable possibility for this discrepancy is that the DM status more closely correlates with the poor cardiac function in CHF patients [10, 20].