ACE and heart failure: Pooled RAAS blockade reduced the risk for heart failure hospitalisation (RR=0.90, 95% CI: 0.82 to 0.98, p=0.01, n=11 765), though ACE inhibitors (RR: 0.86, 95% CI: 0.64 to 1.15, p=0.32, n=1019) and ARB (RR 0.92, 95% CI: 0.83 to 1.02, p=0.13, n=7301) had no effect individually (online supplementary figure 3A and figure 4).