COL4A5 and focal segmental glomerulosclerosis: Of note, five SRNS/FSGS patients had LP variants in COL4A3, COL4A4 and COL4A5 (one, one and three patients, respectively) including a single novel LP COL4A3 variant, c.698G>A, p.(Gly233Glu), in a patient with a dominant family history of FSGS (patient 4) which tracked with disease in an affected brother.