However, given the low incidence of SRNS, the young age of onset (<5 years, two with CNS) and the low frequency/absence of the variants in databases of subjects without known renal disease it is possible that there are additional NPHS1/NPHS2 variants in unsequenced intronic or promoter regions which may act in combination to cause the phenotype in these patients. The gene discussed is NPHS1; the disease is kidney disorder.