PTPRO and hereditary disease: Among the 52 VUS in these patients, the most frequently involved genes were: 28.9% in collagen genes; 7.7% each in NPHS1 and NPHS2; and 5.8% each in INF2, MYH9, PLCE1 and PTPRO. Of the 71 patients with likely genetic disease, 11 cases had 12 additional VUS in genes other than the main causative one for that patient, most frequently collagen genes in 41.7% and WT1 in 16.7%.