NLRP3 and Salmonella Infections: In addition, our results showed that inhibition of Clic1 and Clic5 in Clic4–/– BMDMs could significantly inhibited cytosolic LPS-induced non-canonical NLRP3 inflammasome activation, but had no effects on cytosolic dsDNA-induced AIM2 inflammasome or salmonella infection-induced NLRC4 inflammasome activation (Supplementary Fig. 4a–c).