Glargine and degludec (both available as U100 insulin or 100 U/mL) were modified to deliver more prolonged and stable pharmacokinetic and pharmacodynamic characteristics compared to NPH insulin: 1) a protracted duration of action, permitting once-daily dosing, 2) a reduction in clinically important rates of hypoglycaemia (including nocturnal and severe hypoglycaemia), and 3) lower within- and between-subject variability, leading to more consistent and predictable glycaemic control10, 20, 21. Here, INS is linked to Hypoglycemia.