CXCL12 and acute myeloid leukemia: In agreement with the known functions of CXCR4 in supporting cell anchorage in the BM microenvironment, we observed that PF-06747143 inhibits chemotaxis of AML cell lines and primary AML cells in response to CXCL12, in a manner comparable to the small molecule CXCR4 inhibitors AMD3100 and TN140.