CD4 and colitis: Other NRs such as the VDR are protective during colitis in CD4+ Th17 T cells; however, VDR-deficient CD8+ T cells, especially in combination with naive CD4+ T cells, result in aggravated colitis in Rag-deficient recipients due to enhanced proliferation and increased IFNγ and IL-17 levels in the gut.36 37 Surprisingly, our results showed that the loss of Nr2f6 in CD4+ T and other immune cells enhanced inflammation neither in the transfer colitis model nor in BM chimeras.