ERN1 and malignant colon neoplasm: NR2F1 (COUP-TFI), together with the inositol-requiring enzyme 1, suppresses microsomal triglyceride transfer protein expression at a transcriptional and post-transcriptional stage in undifferentiated intestinal cells and thereby restricts apoB lipoprotein biosynthesis.39 COUP-TFII (NR2F2) directly regulates the transcription and expression of SNAIL1 in human colon cancer tissue and thereby correlates with the inhibition of the expression of adhesion molecules such as ZO-1, E-cadherin and β-catenin and subsequently metastatic potential of colorectal adenocarcinoma cells.40