The study showed that the effective rates for patients with MMP-2 C-1306T C/C genotype and MMP-9 C-1562T T/T genotype were higher than that in patients carrying other genotypes, which indicated that MMP-2 and MMP-9 gene polymorphism had relevance with the efficacy of UTI in the treatment of SAP. The gene discussed is MMP2; the disease is bacterial urinary tract infection.