Our data, showing that CDK6 phosphorylates and thereby stabilizes FOXO3, are highly reminiscent of the effects elicited on FOXM1, a related transcription factor, that, following phosphorylation by CDK4 and CDK6, is stabilized and transactivated to prevent senescence of cancer cells (Anders et al, 2011). The gene discussed is FOXO3; the disease is cancer.