NTRK2 and bacterial meningitis: Early studies reported that adjuvant therapy involving BDNF protects the brain from three distinct forms of injury in experimental bacterial meningitis [28]; however, here, we investigated the effects of BDNF/TrkB interaction on the inflammatory response and hippocampal apoptosis, as well as its effect on other potential intracellular signaling pathways responsible for this protective activity associated with PM.