S100A12 and asthma: These proteins are involved in multiple biological process, including immunity, inflammatory, chemokines, protease, protease inhibitor, metabolism, transport, hydrolase, and vasculogenesis etc. We observed a significant increase of A2M, ANXA1, APOA2, ELANE, GPI, S100A8, S100A9, and S100A12 in all three asthmatic groups, among which S100A8, S100A9, and S100A12 were previously-reported biomarkers for asthma (Table 2).