Cardiac troponin levels increase in response to clinical and subclinical myocardial ischaemia and is currently used to aid the diagnosis of myocardial infarction [17] while NT-proBNP is released by the heart in response to increased pressure on the ventricular wall with low levels used in clinical practice to rule out heart failure [16]. The gene discussed is NPPB; the disease is myocardial infarction.