In patients with CKD stage 2, levels are reported to be nearly 300 ng/mL, and drop below 10 in patients with CKD stage 5, while no uromodulin is detected in blood of anephric persons [51].The highest concentrations of uromodulin in persons without CKD were suggested to be due to the fact that no evasion mechanism for tubular function exists in contrary to glomerular filtration [8]. Here, UMOD is linked to chronic kidney disease.