We have previously demonstrated that Notch1 acts as a tumor suppressor in NE cancers, as the overexpression of Notch1 in carcinoid and medullary thyroid cancer cell lines at the transcriptional level resulted in inhibition of NE cancer cell growth and suppression of NE tumor markers and hormones 28, 29, 47. The gene discussed is NOTCH1; the disease is medullary thyroid gland carcinoma.