Multivariable analysis of long-term (20 years) breast cancer-specific survival by STO-3 trial arm in the 70-gene high-risk and the low-risk subgroups was performed using Cox proportional hazard modeling adjusting for classical patient and tumor characteristics (age and calendar period of diagnosis, progesterone receptor status, HER2 status, Ki-67 status, tumor grade, and tumor size). This evidence concerns the gene ERBB2 and breast cancer.