We have recently characterized two CSC subpopulations within moderately differentiated oral tongue squamous cell carcinoma (MDOTSCC) with an OCT4− subpopulation within the tumor nests (TNs) that also expresses EMA; and an OCT4+ subpopulation within the peri-tumoral stroma that does not express EMA (6). The gene discussed is POU5F1; the disease is neoplasm.