Membrane growth factor receptors (TKRs) were demonstrated to be highly expressed in chordomas: scatter factor/hepatocyte growth factor receptor (c-Met), epidermal growth factor receptor (EGFR/HER1) and different phosphorylated platelet-derived growth factor receptors (PDGFRs) seem to play a key role in tumor proliferation (11); this suggests a potential role of tyrosine-kinase receptor inhibitor as therapeutics. This evidence concerns the gene NTRK1 and chordoma.