Notably, microvascular endothelial cells derived from subcutaneous adipose tissue of patients with uncomplicated malaria and fatal CM were demonstrated to differ in their endothelial inflammatory response to TNF stimulation ex vivo in that MCP-1/CCL2 and IL-6 were induced to a larger extent in endothelial cells derived from CM patients. The gene discussed is CCL2; the disease is cutaneous mastocytosis.