While cell culture provides a model for replicating disease states associated with the deterioration of retinal tissue during AMD, the stimuli leading to enhanced VEGF secretion from RPE cells and the subsequent neovascularization of the choroid are still not fully understood [22, 23], and little is known about how VEGF production is regulated in the eye [9]. The gene discussed is VEGFA; the disease is age-related macular degeneration.