EDN1 and chronic kidney disease: Surgical reduction of renal mass in TP receptor knockout (TP-R−/−) mice demonstrated that activation of TP receptors mediated the increase in endothelin-1 (ET-1), reactive oxygen species (ROS), and microvascular remodeling and enhanced contractions in microvessels in chronic kidney disease [7], suggesting that TXA2 and its receptors were involved in the development of acute and chronic kidney injury.