DDX41 and dengue disease: The recent report that cross-reactive anti-E Abs contributed significantly to neutralizing activities against both exposed and non-exposed DENV serotypes after secondary DENV infection not only provides an explanation for the multitypic neutralizing Abs (Tsai et al., 2015), but also suggests a strategy of sequential heterotypic immunization with two or three serotypes of live-attenuated dengue vaccine to mimic natural DENV infection and induce immunity against all four serotypes.