These were a KCNH2 Arg176Trp variant, which has been reported as a founder mutation associated with a prolonged QT interval in Finnish LQTS families, and alters ion-channel activity in vitro, and an SCN5A Pro1090Leu, which has been reported previously in LQTS and in a case of sudden cardiac death (16). Here, KCNH2 is linked to familial long QT syndrome.