Prophylactic valproate suppresses NF-κB activation in the trigeminocervical complex (56) as well as, prophylactic atorvastatin suppresses NF-κB activation in trigeminal nucleus caudalis (57); both alleviate nitroglycerin-induced migraine, indicating a vital role of NF-κB activation in migraine pathogenesis (56–58). The gene discussed is NFKB1; the disease is migraine disorder.