When OPCs were exposed to CSF of NMO patients, it was found that most of the enzymes involved in glycolysis including Gpi, Aldoc (Fructose 1,6-bisphosphate aldolase), Gapdh, Tpi, Pgk1, Eno1, Pgam, Eno1, Eno2, Pk, and Pkm2 (Figures 2B–F,H–K); the related TCA cycle enzymes including Pdha1, Aco2, Idh, Ogdh, Sdh, and Mdh2 (Figures 3A–F); and the mitochondrial electron chain enzymes (MT-ND2, Cyc1, Cox, ATP5a1, and ATP5b) were strongly reduced in gene expression as compared to neurological controls (Figures 4A–E). The gene discussed is ACO2; the disease is neuromyelitis optica.