Because modalities of RAGE inhibition vary among published studies, and because its modalities may directly impact its effects in a given model, this study was designed to investigate the influence of a treatment with either sRAGE or anti-RAGE mAb on the features of experimental ARDS, including AFC, and on lung expression of alveolar epithelial channels in a translational model of acid-induced lung injury13, 26. Here, AGER is linked to acute respiratory distress syndrome.