Pathways associated with cancer are also enriched in the C+/+/Tia1−/− testis, and the genes Psrc1, Ano3 and Zfp365, all upregulated in C+/+/Tia1−/− testis (Fig. 6A), are regulated by the tumor suppressor p5368–70. The gene discussed is PSRC1; the disease is cancer.