Our perturbation results suggest that in bladder cancer (i) double knockout of ZEB1 in combination with either SNAI1, TWIST1, NFKB1; (ii) knockout of ZEB1 and activation of CDH1; or (iii) knockout of SMAD2/3/4 in combination with TWIST1 or NFKB1 reduces EMT to 1. The gene discussed is CDH1; the disease is urinary bladder cancer.