More specifically, TGFBR1 and FGFR1 in combination with highly expressed E2F1 induce the most invasive phenotype in bladder cancer, whereas in breast cancer, it is the combined action of TGFBR2, EGFR, and E2F1 that triggers high levels of invasiveness. The gene discussed is TGFBR1; the disease is urinary bladder carcinoma.