Similarly, we expanded the breast cancer input layer with the hyaluronan-mediated motility receptor (HMMR) connected to FN1; the TGFBR connected to SNAI1 and SNAI2; the interLeukin 1 receptor type I (IL1R1) and the thyroid hormone receptor beta (THRB) connected to TRAF1 and MYC, respectively. The gene discussed is IL1R1; the disease is breast cancer.