Based on the above-presented background and taking into account the results shown in Fig. 2, revealing SERS intensity increase related to proteins and intensity decrease associated with lipids, it is possible to argue that necrosis is the main process responsible for cell death of the 4T1 breast cancer cells groups treated with PDT using the NE/PS5 and NE/PS10 complexes. The gene discussed is TAS2R12P; the disease is breast cancer.