Since druggable targets found in sporadic meningioma, such as AKT1 and SMO, were not observed within our cohort of 31 RIMs, our findings are relevant in light of current and future targeted clinical trials for meningioma, and indicate that effective therapies for meningioma in childhood cancer survivors may be distinct from precision medicine approaches employed for sporadic meningioma. Here, SMO is linked to meningioma.