LTF and allergic rhinitis: 2016), and it has been reported that the single intranasal administration improved allergic rhinitis in mice (Wang et al. 2013). However, native human lactoferrin had antigenicity and generated specific IgG against human lactoferrin in mice, in which iron binding capacity or its glycosylation may contribute to its antigenicity (Almond et al. 2012, 2013) Lactoferrin from cow milk has been correlated with the severity of atopic dermatitis (Röckmann et al. 2014).