NPHS2 and nephrosis: 1986; Inokuchi et al. 1996). PA‐induced nephrosis specifically leads to podocyte injury; foot process effacement, and decreased expression of slit diaphragm proteins such as nephrin and podocin, concomitant with the onset of proteinuria (Caulfield et al. 1976; Thakur et al. 1988; Lowenborg et al. 2000; Guan et al. 2004). Previous evidence indicates that reactive oxygen metabolites could be important mediators of tissue injury in PA‐induced nephrosis (Diamond et al. 1986; Thakur et al. 1988; Gwinner et al. 1997).