Furthermore, overproduction of C-type natriuretic peptide by chromosomal translocation [31, 32] and gain-of-function mutations in natriuretic peptide receptor-2 (NPR2) gene have been reported to be responsible for overgrowth syndromes [33, 34] or extremely tall stature without skeletal deformities [35]. The gene discussed is NPR2; the disease is overgrowth syndrome.