A large COPD eQTL study that used whole blood and sputum gene expression data from 121 ECLIPSE subjects found eQTLs near previously reported GWAS loci (FAM13A, CHRNA3/5, HHIP), suggesting hypotheses for how association signals are functionally related to COPD [210]. The gene discussed is HHIP; the disease is chronic obstructive pulmonary disease.