To test whether M4 PAM could also correct the AGS phenotype, we injected Fmr1−/y and WT littermates with vehicle (10% DMSO + 10% Tween-80 in PBS) or 56 mg/kg VU0152100, a dose previously shown to be effective in reducing aberrant behaviors in mouse and rat models of psychosis while having no effect on M4 KO mice (Byun et al., 2014). The gene discussed is FMR1; the disease is psychotic disorder.