In addition, the levels of Aβ‐metabolism‐associated enzymes, including IDE, NEP, cathepsin B, LRP1, and RAGE, were not significantly affected following HDAC3 inhibition (P > 0.05; Fig. 3H,I), suggesting that HDAC3 inhibition might decrease the expression of PS1 and ameliorate the amyloid burden in the hippocampus of APP/PS1 mice. This evidence concerns the gene CTSB and amyloidosis.