Considering that inhibition of miR-21 expression reduced fibrosis in the mildly affected dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy [21], we next investigated if removal of miR-21 would have propitious effects in the milder LAMA2-CMD dy2J/dy2J mouse model. This evidence concerns the gene LAMA2 and Duchenne muscular dystrophy.