Laminin-deficient congenital muscular dystrophy type 1A (LAMA2-CMD) is a severe form of muscular dystrophy caused by mutations in the LAMA2 gene encoding the laminin α2 chain that together with laminin β1 and γ1 chains form the heterotrimeric molecule laminin-211. This evidence concerns the gene LAMB2 and congenital muscular dystrophy.