Regulatory T cells (CD4+CD25+FoxP3+), well known to protect against atherosclerosis [24] and shown to be affected in Flt3-/-Ldlr-/- mice that lack CD103+ cells, were unaltered in the spleen of Ldlr-/-Batf3-/- mice (Fig 4C). This evidence concerns the gene CD4 and atherosclerosis.