IL25 and chronic rhinosinusitis with nasal polyps: As IL-25 is generally considered to be the dominant innate cytokine with a critical role in the pathogenesis of polyp formation in CRSwNP, [13] and because expression of IL-25 is known to be involved in airway remodeling, [19] in the present study, we examined whether IL-25 influences tissue remodeling in CRSwNP.