Malinsky et al. reported a higher expression of MMP-1 mRNA in patients with nasal polyps than in the controls, suggesting that MMP-1 (also known as collagenase 1 and known to initiate degradation of type I and III fibrillar collagen) could play an important role in CRSwNP [34]. This evidence concerns the gene MMP1 and chronic rhinosinusitis with nasal polyps.